Parameters | ||
---|---|---|
Concentration | Cblood | Concentration in the blood |
Cbrain | Concentration in the brain | |
CCSF | Concentration in the ventricles | |
Volume | V1 | Distribution volume in the body |
V2 | Volume in the brain | |
V3 | Ventricle volume | |
Clearance (ml/min per rat) | PS1 | Passive clearance in the BBB |
PS2 | Clearance for exchange across the ependymal layer | |
PS3 | Passive clearance in the BCSFB | |
PS4 | Active efflux in the BBB | |
CLbulk flow | Bulk flow rate (0.0029) (Suzuki et al., 1985) | |
CL | Total body clearance | |
Unbound fraction | fblood | Unbound fraction in the blood |
fu,brain | Unbound fraction in the brain | |
fu,CSF | Unbound fraction in the CSF | |
Others | kinf | Infusion rate |
Free parameters for fitting | A | Ratio of PS1 to PS3 |
B | Scaling factor for P-gp | |
C | Scaling factor for Bcrp | |
D | Coefficient in eq. 7 |
BBB, blood-brain barrier; BCSFB, blood-cerebrospinal fluid barrier; CL, clearance; CSF, cerebrospinal fluid; V, volume.