Summary of mean atorvastatin liver and blood concentration (±S.D.) when administered 5 mg/kg i.v. in the absence and presence of 20 mg/kg i.v. rifampin or 35 mg/kg ketoconazole in various animal models
Livers were sampled at 15 minutes postdose (N = 3); *P < 0.05.
| Liver Concentration (nmol/g tissue) | Blood Concentration (µM) | |||||
|---|---|---|---|---|---|---|
| Wild Type | Cyp3a Knockout | Oatp1a/1B Knockout | Wild Type | Cyp3a Knockout | Oatp1a/1B Knockout | |
| Vehicle | 1.15 (0.61) | 44.5 (15.8) | 1.80 (0.45) | 0.351 (0.185) | 0.544 (0.244) | 1.02 (0.45) |
| Rifampin | 4.31 (0.54)* | 40.6 (10.0) | 3.72 (0.30)* | 13.0 (7.3) | 3.04 (0.54) | 4.30 (0.77) |
| Ketoconazole | 24.3 (5.5)* | 64.0 (12.7)* | 31.6 (8.2)* | 0.714 (0.008) | 1.61 (0.25) | 2.48 (0.51) |