Excretion of radioactivity in the bile and urine of chimeric and control mice as a fraction of the administered dose of [3H]lamotrigine, [3H]MRK-A, [3H]diclofenac, and [3H]propafenone
Data are presented as mean ± S.D. from three animals except where data from only two animals were available, in which cases means along with individual animal data (in parentheses) are listed.
| Radioactivity Excretion | |||
|---|---|---|---|
| Chimeric Mice | Control Mice | ||
| % of administered dose | |||
| [3H]lamotrigine | Bile | 3.3 (3.0, 3.6) | 8.0 ± 2.1 |
| Urine | 43 (42, 44) | 26 ± 6.1 | |
| Feces | 2.0 (1.8, 2.1) | 1.8 ± 0.9 | |
| Total | 48 (48, 49) | 36 ± 7.5 | |
| [3H]MRK-A | Bile | 58 ± 30 | 49 ± 5.3 |
| Urine | 5.1 ± 2.8 | 14 ± 5.2 | |
| Feces | 4.1 (3.1, 5.2) | 2.4 ± 1.3 | |
| Total | 65 ± 34 | 65 ± 11 | |
| [3H]diclofenac | Bile | 25 ± 6.6 | 21 ± 4.2 |
| Urine | 41 ± 12 | 35 ± 7.0 | |
| Feces | 1.7 ± 0.9 | 1.5 (0.6, 2.4) | |
| Total | 68 ± 9.1 | 57 ± 12 | |
| [3H]propafenone | Bile | 14 (14, 15) | 6.1 ± 0.7 |
| Urine | 44 (38, 50) | 83 ± 2.7 | |
| Feces | 3.0 (2.4, 3.7) | N.D. | |
| Total | 61 (55, 68) | 89 ± 3.0 | |
N.D., not determined.