TABLE 1

Correlation between relative intensity of identified proteins and LO-hydrolyzing active peak I (fraction no. 26-32) on gel-filtration chromatogram

Among the 1160 proteins identified, the top 30 candidates with high correlation coefficient between relative intensity of the identified proteins and LO-hydrolyzing active peak I (fraction no. 26-32) on gel-filtration chromatogram are listed. Identified peptides for each protein are listed in Supplemental Table 1.

Rank	Uniprot ID	Protein Description	Gene Name	Correlation Coefficient
1	Q96G03	Phosphoglucomutase-2	PGM2	0.9966
2	Q9UBQ7	Glyoxylate reductase/hydroxypyruvate reductase	GRHPR	0.9963
3	P18669^*	Phosphoglycerate mutase 1	PGAM1	0.9953
4	P62495	Eukaryotic peptide chain release factor subunit 1	ETF1	0.9930
5	P36955	Pigment epithelium-derived factor	SERPINF1	0.9824
6	Q9HAT2^*	Sialate O-acetylesterase	SIAE	0.9815
7	P35270	Sepiapterin reductase	SPR	0.9758
8	O75131	Copine-3	CPNE3	0.9741
9	Q99798	Aconitate hydratase, mitochondrial	ACO2	0.9736
10	O60888	Protein CutA	CUTA	0.9728
11	Q99729	Heterogeneous nuclear ribonucleoprotein A/B	HNRNPAB	0.9714
12	P09960^*	Leukotriene A-4 hydrolase	LTA4H	0.9703
13	O76003	Glutaredoxin-3	GLRX3	0.9693
14	P23141^*	Liver carboxylesterase 1	CES1	0.9653
15	O43598^*	Deoxyribonucleoside 5-monophosphate N-glycosidase	RCL	0.9632
16	Q13838^*	Spliceosome RNA helicase DDX39B	DDX39B	0.9602
17	P40926	Malate dehydrogenase, mitochondrial	MDH2	0.9599
18	Q9H0R4	Haloacid dehalogenase-like hydrolase domain-containing protein 2	HDHD2	0.9578
19	O15305	Phosphomannomutase 2	PMM2	0.9575
20	P21695	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	GPD1	0.9519
21	Q9Y3F4	Serine-threonine kinase receptor-associated protein	STRAP	0.9478
22	P13284	Gamma-interferon-inducible lysosomal thiol reductase	IFI30	0.9458
23	P10768^*	S-formylglutathione hydrolase	ESD	0.9432
24	P49407	Beta-arrestin-1	ARRB1	0.9432
25	Q2TAA2^*	Isoamyl acetate-hydrolyzing esterase 1 homolog	IAH1	0.9430
26	P14866	Heterogeneous nuclear ribonucleoprotein L	HNRNPL	0.9427
27	Q0VGL1	UPF0539 protein C7 or f59	C7orf59	0.9427
28	Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	HNRNPUL1	0.9389
29	Q9UHA4	Ragulator complex protein LAMTOR3	LAMTOR3	0.9340
30	Q13813	Spectrin alpha chain, brain	SPTAN1	0.9333

↵* Hydrolase domain annotated by Uniprot.