Pharmacokinetic parameters for ABT after administration to rats
Pharmacokinetic parameters for ABT in rats were obtained as an integral part of midazolam/ABT and NVS-CRF38/ABT interaction studies. Data are expressed as mean and standard deviation of four rats.
| Parameter | Female Wistar Rats | Male Sprague-Dawley Rats | ||
|---|---|---|---|---|
| aOral (n=4) | ai.p. (n=4) | bOral (n=4) | ci.p. (n=4) | |
| Dose (mg/kg) | 100 | 100 | 100 | 100 |
| Cmax (µM) | 94 ± 40 | 265 ± 42 | **268 ± 11 | **579 ± 53 |
| Tmax (hr) | 16 ± 16 | 4.1 ± 1.1 | 2.7 ± 0.6 | *2.4 ± 0.3 |
| T1/2 (hr) | 12.3 ± 0.3 | 19.6 ± 2.0 | **7.0 ± 0.7 | **10.6 ± 1.2 |
| AUC0−t (µM•hr) | 3,032 ± 1,557 | 7,638 ± 119 | *5,706 ± 325 | 8,265 ± 1,531 |
| AUC0−∞ (µM•hr) | 3,153 ± 1,618 | 8,241 ± 1,449 | *5,723 ± 325 | 8,359 ± 1,591 |
↵a Two hours prior to a 100 mg/kg oral dose of NVS-CRF38.
↵b Two hours prior to a 2 mg/kg oral dose of midazolam maleate.
↵c Two hours prior to a 0.5 mg/kg s.c. dose of midazolam maleate.
↵* P < 0.05 (Student’s t test) versus values in Wistar rats.
↵** P < 0.01 (Student’s t test) versus values in Wistar rats.