TABLE 1

Plasma concentration, brain concentration, and brain-to-plasma ratio after oral administration of GNE-317 (50 mg/kg) or pictilisib (150 mg/kg) to U87 tumor-bearing mice

Results reported as mean ± S.D. (n = 3).

Compound	Time	Plasma	Normal Brain
Compound	Time	Plasma	Brain	Brain-to-Plasma Ratio	Free Brain-to-Free Plasma Ratio
	h	µM	µM
GNE-317	1	2.01 ± 0.48	2.50 ± 0.24	1.32 ± 0.48	0.48 ± 0.17
	6	1.86 ± 0.93	2.02 ± 1.13	1.10 ± 0.21	0.398 ± 0.075
Pictilisib	1	7.77 ± 0.26	0.16 ± 0.11	0.021 ± 0.014	0.0059 ± 0.0038
	6	5.26 ± 0.33	0.0669 ± 0.0060	0.0127 ± 0.0011	0.00353 ± 0.00032