Compound | Time | Plasma | Normal Brain | ||
---|---|---|---|---|---|
Brain | Brain-to-Plasma Ratio | Free Brain-to-Free Plasma Ratio | |||
h | µM | µM | |||
GNE-317 | 1 | 2.45 ± 0.45 | 3.79 ± 1.09 | 1.53 ± 0.21 | 0.555 ± 0.076 |
6 | 1.61 ± 0.35 | 1.87 ± 0.38 | 1.17 ± 0.02 | 0.422 ± 0.007 | |
Pictilisib | 1 | 5.51 ± 1.21 | 0.150 ± 0.057 | 0.0271 ± 0.0089 | 0.00752 ± 0.00245 |
6 | 7.25 ± 0.73 | 0.178 ± 0.061 | 0.0247 ± 0.0082 | 0.00684 ± 0.00229 |