TABLE 2

Plasma concentration, brain concentration, and brain-to-plasma ratio after oral administration of GNE-317 (50 mg/kg) or pictilisib (150 mg/kg) to GS2 tumor-bearing mice

Results reported as mean ± S.D. (n = 3).

Compound	Time	Plasma	Normal Brain
Compound	Time	Plasma	Brain	Brain-to-Plasma Ratio	Free Brain-to-Free Plasma Ratio
	h	µM	µM
GNE-317	1	2.45 ± 0.45	3.79 ± 1.09	1.53 ± 0.21	0.555 ± 0.076
	6	1.61 ± 0.35	1.87 ± 0.38	1.17 ± 0.02	0.422 ± 0.007
Pictilisib	1	5.51 ± 1.21	0.150 ± 0.057	0.0271 ± 0.0089	0.00752 ± 0.00245
	6	7.25 ± 0.73	0.178 ± 0.061	0.0247 ± 0.0082	0.00684 ± 0.00229