Drug | CLint,app (ml/min/mg) (Error)a | Estimated % Contribution | ||||
---|---|---|---|---|---|---|
Total | +Ketoconazole | +CYP3cide | All CYP3A | CYP3A4 Only | Calc. CYP3A5 | |
Atazanavir | 51 (0.12) | 12 (0.45) | 54 (0.12) | 76 | <10 | 82 |
Vincristine | 77 (0.12) | 9.2 (0.50) | 67 (0.15) | 88 | 13 | 75 |
Midazolam | 350 (0.03) | 28 (0.13) | 200 (0.02) | 92 | 43 | 49 |
Vardenafil | 89 (0.08) | 8.0 (1.0) | 52 (0.08) | 91 | 42 | 49 |
Otenabant | 41 (0.06) | 4.3 (0.22) | 24 (0.06) | 90 | 41 | 48 |
Verapamil | 150 (0.12) | 7.2 (0.70) | 69 (0.16) | 95 | 54 | 41 |
Tacrolimus | 870 (0.02) | 75 (0.13) | 430 (0.02) | 91 | 51 | 41 |
Quinine | 13 (0.15) | 0.43 (5.53) | 6.0 (0.39) | 97 | 54 | 43 |
Rimonabant | 87 (0.02) | 32 (0.03) | 63 (0.02) | 63 | 28 | 36 |
Indinavir | 250 (0.03) | 33 (0.25) | 120 (0.07) | 87 | 52 | 35 |
Miraviroc | 32 (0.03) | 2.8 (0.33) | 13 (0.03) | 91 | 59 | 32 |
Nisoldipine | 390 (0.02) | 31 (0.35) | 140 (0.07) | 92 | 64 | 28 |
Triazolam | 30 (0.04) | 2.5 (0.25) | 9.9 (0.08) | 92 | 67 | 25 |
Terfenadine | 180 (0.01) | 23 (0.12) | 65 (0.05) | 87 | 64 | 23 |
Cilostazol | 36 (0.08) | 4.5 (0.30) | 13 (0.12) | 88 | 64 | 24 |
Simvastatin | 7700 (0.02) | 610 (0.08) | 1900 (0.03) | 92 | 75 | 17 |
Ebastine | 63 (0.03) | 6.8 (0.28) | 17 (0.18) | 89 | 73 | 16 |
Buspirone | 170 (0.03) | 18 (0.21) | 43 (0.09) | 89 | 75 | 15 |
Diltiazam | 28 (0.05) | 6.0 (0.21) | 10 (0.07) | 79 | 64 | 14 |
Nifedipine | 140 (0.04) | 6.5 (0.99) | 26 (0.46) | 95 | 81 | 14 |
Saquinavir | 3500 (0.01) | 19 (0.20) | 390 (0.03) | 99 | 89 | 11 |
Testosterone | 140 (0.05) | 110 (0.04) | 120 (0.03) | 21 | 14 | <10 |
Dronedarone | 180 (0.05) | 17 (0.17) | 31 (0.10) | 91 | 83 | <10 |
Quetiapine | 130 (0.06) | 26 (0.34) | 35 (0.16) | 80 | 73 | <10 |
Felodipine | 160 (0.11) | 22 (0.23) | 29 (0.17) | 86 | 82 | <10 |
Oxycodone | 5.7 (0.07) | 4.0 (0.05) | 4.3 (0.07) | 30 | 25 | <10 |
Quinidine | 11 (0.42) | 0.80 (1.72) | 1.3 (2.99) | 93 | 88 | <10 |
Loratadine | 550 (0.05) | 340 (0.07) | 360 (0.09) | 38 | 35 | <10 |
Alprazolam | 1.3 (0.19) | 0.49 (0.58) | 0.53 (0.53) | 62 | 59 | <10 |
Everolimus | 58 (0.12) | 1.9 (0.97) | 1.9 (0.84) | 97 | 97 | <10 |
Clarithromycin | 11 (0.06) | 1.7 (0.31) | 1.6 (0.35) | 85 | 85 | <10 |
Erythromycin | 17 (0.22) | 5.5 (0.73) | 5.4 (0.81) | 68 | 68 | <10 |
↵a The error is estimated as the S.E. of the in vitro half-life divided by the mean half-life for each incubation condition.