Intrinsic clearance (CLint) of cytochrome P450 CYP3A metabolized drugs measured in recombinant CYP3A4 and CYP3A5
| Drug | CLint (ยตl/min/pmol P450) | ||
|---|---|---|---|
| CYP3A4 | CYP3A5 | Ratio | |
| Atazanavir | 1.2 | 2.4 | 2.0 |
| Vincristine | 0.58 | 2.8 | 4.8 |
| Midazolam | 16 | 35 | 2.2 |
| Vardenafil | 2.8 | 18 | 6.4 |
| Otenabant | 9.8 | 8.2 | 0.84 |
| Verapamil | 12 | 4.4 | 0.36 |
| Tacrolimus | 7.9 | 17 | 2.1 |
| Quinine | 0.84 | 1.1 | 1.4 |
| Rimonabant | 6.6 | 46 | 7.0 |
| Saquinavir | 40 | 25 | 0.63 |
| Triazolam | 1.8 | 2.0 | 1.1 |
| Terfenadine | 21 | 14 | 0.64 |
| Cilostazol | 6.2 | 5.3 | 0.84 |
| Simvastatin | 240 | 170 | 0.72 |
| Ebastine | 8.3 | 1.2 | 0.15 |
| Buspirone | 20 | 5.0 | 0.25 |
| Diltiazem | 3.6 | 1.8 | 0.50 |
| Testosterone | 3.4 | 0.43 | 0.13 |
| Quetiapine | 19 | 3.3 | 0.17 |
| Oxycodone | 0.50 | <0.06 | <0.11 |
| Quinidine | 0.85 | 0.39 | 0.46 |
| Loratadine | 34 | 1.7 | 0.05 |
| Alprazolam | 0.25 | 0.09 | 0.37 |
| Clarithromycin | 2.0 | 0.5 | 0.23 |