CLint (µl/min/mg) | Estimated % Contribution | |||||
---|---|---|---|---|---|---|
Control | Ketoconazole | CYP3cide | CYP3A | CYP3A4 | CYP3A5 | |
Alprazolam | ||||||
1′-Hydroxylation | 1.9 | 0.14 | 1.2 | 93 | 37 | 56 |
4-Hydroxylation | 5.1 | 0.32 | 1.3 | 94 | 75 | 19 |
Midazolam | ||||||
1′-Hydroxylation | 260 | 8.7 | 150 | 97 | 42 | 55 |
4-Hydroxylation | 21 | 1.9 | 11 | 91 | 47 | 44 |
Triazolam | ||||||
1′-Hydroxylation | 42 | 1.8 | 10 | 96 | 76 | 20 |
4-Hydroxylation | 14 | 1.4 | 4.1 | 90 | 71 | 19 |
Testosterone | ||||||
6β-hydroxylation | 82 | 3.5 | 16 | 96 | 80 | 16 |
Tamoxifen | ||||||
N-demethylation | 170 | 35 | 52 | 79 | 69 | 10 |
Atazanavir | ||||||
Phenyl p-hydroxylation | 16 | 1.8 | 11 | 89 | 31 | 58 |
t-Butyl hydroxylation | 21 | 1.8 | 11 | 91 | 48 | 43 |