TABLE 2

Kinetics of M2 and M4 formation in HLMs

Parameter	Metabolite Formation
Parameter	KRO-105714 to M2^{^a}	M2 to M4
K_m (μM)	4.4	2.3
V_max (pmol/min per mg protein)	39.4	7.2
CL_int (μl/min per mg protein)	9.0	3.1

↵^a Amount of product is a combination of generated M2 and M4.