Total Urine Radioactivity | |||||||
---|---|---|---|---|---|---|---|
Unknown Metabolite | Desmethyl Sulfate | Desmethyl | Carboxylic Acid | Hydroxy | Sulfate | Tedizolid | |
% | |||||||
Tedizolid phosphate administered intravenously to rats (0–6-hour samples) | |||||||
Male | 1.5 | 21.3 | 1.6 | 7.5 | 0.5 | 65 | 2.6 |
Female | 3.3 | 0.3 | 14.0 | 8.3 | 0.8 | 65 | 8.3 |
Tedizolid phosphate administered orally to rats (0–6-hour samples) | |||||||
Male | 2.4 | 24.5 | 0.6 | 7.8 | 0.1 | 62.3 | 2.3 |
Female | 3.3 | 0.9 | 11.8 | 9.2 | 1.0 | 67.8 | 6 |
Tedizolid phosphate administered intravenously to dogs (0–6-hour samples) | |||||||
Male | — | 1.8 | 66.2 | 2.6 | — | 27.9 | 1.5 |
Female | — | — | 56.5 | <1.0 | — | 41.8 | 1.5 |
Tedizolid phosphate administered orally to dogs (0–12-hour samples) | |||||||
Male | 1.0 | — | 39.6 | 1.1 | — | 57.6 | <1.0 |
Female | — | 2.3 | 60 | — | — | 37.6 | — |