Kinetic parameters of NTCP-, OATP1B1-, OATP1B3-, and OATP2B1-mediated atorvastatin uptake in stably transfected HEK293 cells
| Transporter | Km | Vmax |
|---|---|---|
| µM | pmol min−1 mg protein−1 | |
| NTCP | 185 ± 108 | 2260 ± 1184 |
| OATP1B1 | 0.77 ± 0.24a | 6.61 ± 1.24a |
| OATP1B3 | 0.73 ± 1.45a | 2.29 ± 1.45a |
| OATP2B1 | 2.84 ± 1.63a | 24.27 ± 8.12a |
↵a Km and Vmax values reprinted with permission from Karlgren et al. (2012b). Copyright 2012, American Chemical Society.