TABLE 3

Half-maximal inhibitory concentrations, IC50, and corresponding inhibition constants, Ki, calculated assuming competitive inhibition

CompoundOATP1B1OATP1B3OATP2B1NTCP
IC50KiIC50KiIC50KiIC50Ki
ยตM
Atazanavir0.960.42177.3>40>30>40>40
Cyclosporine1.50.663.11.3>18>134.84.8
Gemfibrozil13058>1000>4207705708989
Lopinavir0.770.34>10>4.2>10>7.4>10>10
Rifampicin5.02.219082>630>470>630>630