Compound | OATP1B1 | OATP1B3 | OATP2B1 | |||
---|---|---|---|---|---|---|
IC50 Atorvastatin | IC50 E17βGa | IC50 Atorvastatin | IC50 E17βGa | IC50 Atorvastatin | IC50 E3Sa | |
µM | ||||||
Atazanavir | 0.96 ± 1.2 | 1.4 ± 1.0 | 17 ± 1.3 | 0.40 ± 1.2 | >40 | 5.2 ± 1.2 |
Cyclosporine | 1.5 ± 1.2 | 1.4 ± 1.2 | 3.1 ± 1.4 | 1.3 ± 1.0 | >18 | 37 ± 1.6 |
Rifampicin | 5.0 ± 1.2 | 1.2 ± 1.2 | 190 ± 1.7 | 1.5 ± 1.1 | >630 | 65 ± 1.2 |
E17βG, estradiol-17β-glucuronide; E3S, estrone-3-sulfate.
↵a IC50 values reprinted with permission from Karlgren et al. (2012b). Copyright 2012 American Chemical Society.