Collection Interval (h) | % of Mean Administered Dose | |||
---|---|---|---|---|
Mean for i.v. Dose | SD | Mean for Oral Dose | S.D. | |
Urine | ||||
0–6 | 36.5 | 3.8 | 33.0 | 10.9 |
6–12 | 5.2 | 0.4 | 8.0 | 2.0 |
12–24 | 2.6 | 0.5 | 3.0 | 0.6 |
24–48 | 2.3 | 0.8 | 2.2 | 0.4 |
48–72 | 0.7 | 0.3 | 0.6 | 0.1 |
72–96 | 0.3 | 0.2 | 0.1 | 0.1 |
96–120 | 0.1 | 0.1 | 0.03 | 0.1 |
120–144 | NS | NS | 0.02 | 0.05 |
144–168 | NS | NS | 0.02 | 0.05 |
Subtotal | 47.5 | 4.1 | 47.0 | 10.0 |
Feces | ||||
0–24 | 0.79 | 0.7 | 4.9 | 6.78 |
24–48 | 21.5 | 16.9 | 21.6 | 10.8 |
48–72 | 16.6 | 10.0 | 13.4 | 6.2 |
72–96 | 5.3 | 7.0 | 3.9 | 3.2 |
96–120 | 3.6 | 5.8 | 0.2 | 0.3 |
120–144 | 0.2 | 0.2 | 0.4 | 0.3 |
144–168 | 0.3 | 0.3 | 0.1 | 0.04 |
168–192 | 0.1 | NA | 0.2 | 0.09 |
192–216 | 0.1 | NA | NS | NS |
Subtotal | 48.3 | 2.9 | 44.7 | 10.2 |
Totala | 95.8 | 2.4 | 91.7 | 16.1 |
NA, not applicable and subject discharged from clinical unit and excluded from calculation of mean and S.D.; NS, no sample obtained.
↵a The total recovery included the radioactivity recovered from toilet tissues (<0.1% of dose per subject).