Metabolite ID | % Bile Radioactivitya | |
---|---|---|
Intravenous Dose 0–2 h Pooled Duodenal Bile | Oral Dose 2–6.5 h Pooled Duodenal Bile | |
M1, M38 | 3.4 | 5.4 |
M2, M39 | 2.7 | 5.2 |
M3, M40 | 5.1 | 4.5 |
M4, M41 | 5.0 | 6.6 |
M18 | 2.0 | 3.4 |
M6 | 2.0 | 2.3 |
M9 | 39.9 | 53.4 |
GSK1322322, M37 | 29.8 | 9.1b |
M6, GSK2998310; M9, GSK2998314; M37, GSK2733752.
↵a Liquid chromatography-tandem mass spectrometry work was completed on the bile extracts (pooled across subjects per period) to identify the metabolites radioprofiled using accelerator mass spectrometry.
↵b M37 was determined to be 4.3% of GSK1322322 from mass spectrum response compared with synthetic standards in pooled human bile, oral dose.