Enzyme | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C18 | CYP2C19 | CYP2D6 | CYP2E1 | CYP2J2 | CYP3A4 | CYP3A5 | CYP3A7 | CYP3A43 | CYP4F2 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CYP1A2 | 1 | Rs = 0.50a | — | Rs = 0.34 | Rs = 0.56a | — | — | — | — | Rs = 0.58a | Rs = 0.38 | — | — | — | — |
P = 0.0002 | P = 0.003 | P < 0.0001 | P = 0.003 | P = 0.0006 | |||||||||||
n = 51 | n = 72 | n = 53 | n = 24 | n = 80 | |||||||||||
CYP2A6 | 1 | Rs = 0.47 | Rs = 0.64b | Rs = 0.64b | — | Rs = 0.52a | — | — | — | Rs = 0.58a | — | — | — | — | |
P = 0.0005 | P < 0.0001 | P < 0.0001 | P = 0.006 | P < 0.0001 | |||||||||||
n = 51 | n = 51 | n = 50 | n = 27 | n = 50 | |||||||||||
CYP2B6 | 1 | Rs = 0.40 | — | — | — | — | — | — | Rs = 0.46 | — | — | — | — | ||
P = 0.0036 | P < 0.0001 | ||||||||||||||
n = 51 | n = 124 | ||||||||||||||
CYP2C8 | 1 | Rs = 0.55a | — | Rs = 0.37 | Rs = 0.61b | — | — | Rs = 0.68b | — | — | — | — | |||
P < 0.0001 | P = 0.001 | P < 0.0001 | P < 0.0001 | ||||||||||||
n = 99 | n = 61 | n = 51 | n = 134 | ||||||||||||
CYP2C9 | 1 | Rs = 0.57a | Rs = 0.40 | — | — | — | Rs = 0.55a | — | — | — | — | ||||
P = 0.005 | P < 0.0001 | P < 0.0001 | |||||||||||||
n = 23 | n = 419 | n = 71 | |||||||||||||
CYP2C18 | 1 | — | — | — | — | — | — | — | Rs = 0.62b | — | |||||
P = 0.002 | |||||||||||||||
n = 23 | |||||||||||||||
CYP2C19 | 1 | Rs = 0.53a | — | — | — | — | — | — | — | ||||||
P = 0.005 | |||||||||||||||
n = 27 | |||||||||||||||
CYP2D6 | 1 | — | — | — | — | Rs = 0.51a | — | — | |||||||
P = 0.002 | |||||||||||||||
n = 36 | |||||||||||||||
CYP2E1 | 1 | — | — | — | — | — | — | ||||||||
CYP2J2 | 1 | — | — | — | — | — | |||||||||
CYP3A4 | 1 | Rs = 0.70*, b | — | — | — | ||||||||||
P < 0.0001* | |||||||||||||||
n = 52* | |||||||||||||||
CYP3A5 | 1 | — | — | — | |||||||||||
CYP3A7 | 1 | — | — | ||||||||||||
CYP3A43 | 1 | ||||||||||||||
CYP4F2 | 1 |
Spearman correlation (Rs) analysis was used. Significant strong correlations are in bold font and significant strong correlations are shown in italic bold font. Nonsignificant correlations are not included (—). Rs, the Spearman correlation coefficient; P, probability value; n, number of subjects.
↵a Rs between 0.50 and 0.59; bRs of .60 and above.
↵* Correlation between CYP3A4 and CYP3A5*1/*3 abundance data from nine studies.