The weighted means, coefficients of variation (CV), ranges, and heterogeneity analysis of the analyzed hepatic cytochrome P450 enzyme abundance data from 50 studies
| Enzyme | Mean | CV (%) | Range* | No. of Livers | Q | I2 | Heterogeneity | Studiesa |
|---|---|---|---|---|---|---|---|---|
| pmol mg−1 | % | % | ||||||
| CYP1A2 | 39 | 78 | 1–263 | 148 | 19.54 | 54 | Medium | [1–10] |
| CYP2A6 | 27 | 86 | 0–191 | 180 | 2.44 | 0 | None | [3, 6, 7, 9, 11] |
| CYP2B6 | 16 | 125 | 0–180 | 504 | 14.55 | 0 | None | [3, 6, 7, 9, 10,12–23] |
| CYP2C8 | 22.4 | 68 | 0–85 | 144 | 3.72 | 0 | None | [6, 7, 9, 24–28] |
| CYP2C9 | 61 | 54 | 0–277 | 120 | 14.36 | 30 | Low | [1, 4, 6, 7, 9, 25–27, 29–31] |
| CYP2C18 | 0.4 | 39 | 0.2–0.7 | 23 | — | — | — | [9] |
| CYP2C19 | 11 | 82 | 0–67 | 76 | 9.81 | 18 | Low | [4, 6, 10, 25–27, 29, 30, 32] |
| CYP2D6 | 12.6 | 74 | 0–75 | 206 | 2.55 | 0 | None | [1-4, 6, 7, 9, 10, 33, 34] |
| CYP2E1 | 64.5 | 53 | 2–201 | 145 | 9.61 | 37 | Low | [1, 3, 5–7, 8, 20] |
| CYP2J2 | 1.2 | 58 | 0–3 | 23 | — | — | — | [9] |
| CYP3A4 | 93 | 81 | 0–601 | 713 | 46.78 | 36 | Low | [2–4, 6, 7, 8, 9, 12, 13, 23, 24, 28, 30–32, 35–47, 48–50] |
| CYP3A5 | 17 | 185 | 0–291 | 250 | 26.16 | 46 | Medium | [6, 9, 35–44, 47, 49, 50] |
| CYP3A7 | 9 | 154 | 0–90 | 54 | 0.68 | 0 | None | [6, 9, 35, 37] |
| CYP3A43 | 2 | 35 | 0–6 | 35 | 72.96 | 99 | High | [6, 9] |
| CYP4F2 | 11.4 | 45 | 1–24 | 23 | — | — | — | [9] |
Q, Cochran’s heterogeneity coefficient; I2, Higgins and Thompson’s heterogeneity index.
↵* Ranges are included where available.
↵a Studies: [1] Olesen and Linnet, 2000; [2] Nakajima et al., 1999; [3] Shimada et al., 1994; [4] Olesen and Linnet, 2001; [5] Seibert et al., 2009; [6] Ohtsuki et al., 2012; [7] Imaoka et al., 1996; [8] Guengerich and Turvy, 1991; [9] Achour et al., 2014a; [10] Venkatakrishnan et al., 2000; [11] Haberl et al., 2005; [12] Totah et al., 2008; [13] Mimura et al., 1993; [14] Code et al., 1997; [15] Ekins et al., 1998; [16] Hanna et al., 2000; [17] Lamba et al., 2003; [18] Lang et al., 2001; [19] Stresser and Kupfer, 1999; [20] Snawder and Lipscomb, 2000; [21] Yang et al., 1998; [22] Hesse et al., 2004; [23] Kharasch et al., 2004; [24] Naraharisetti et al., 2010; [25] Läpple et al., 2003; [26] Jung et al., 1997; [27] Lasker et al., 1998; [28] McSorley and Daly, 2000; [29] Wester et al., 2000; [30] Yamazaki et al., 1998; [31] Yasumori et al., 1993; [32] Yamazaki et al., 1997; [33] Zanger et al., 2001; [34] Langenfeld et al., 2009; [35] Sim et al., 2005; [36] Lin et al., 2002; [37] Tateishi et al., 1999; [38] Wang et al., 2005; [39] Westlind-Johnsson et al., 2003; [40] von Richter et al., 2004; [41] Kamdem et al., 2004;[42] Barter et al., 2010; [43] King et al., 2003; [44] Galetin et al., 2004; [45] Wolbold et al., 2003; [46] Wandel et al., 1998; [47] Kuehl et al., 2001; [48] Paine et al., 1997; [49] Dennison et al., 2007; [50] Wang et al., 2008.