TABLE 3 Comparison of the CYP2D1 nucleotide sequence at 418–421 between the slow and fast metabolizer phenotypes of PK of Cpd-D in male SD rats
Rats with AUC values less than 6.8 and 26.3 μM·hour at the 30 and 100 mg/kg oral administrations, respectively, were designated as “fast” metabolizer phenotypes, and those with AUC values exceeding 127 and 424 μM·hour at the 30 and 100 mg/kg oral administrations, respectively, were designated as “slow” metabolizer phenotypes.