TABLE 3

Pharmacokinetic parameters of brain nicotine and metabolites in EA and AD rats following s.c. nicotine

Data are presented as mean (S.D.).

ParameterNICCOTNNICNNO
EAADEAADEAADEAAD
t1/2 (min)15997449347139137172112
AUC(2–8h) (ng⋅h/g)343 (105)534 (59)706** (58)972 (46)120* (20)78 (13)13 (3.4)19 (3.0)
  • COT, cotinine; NIC, nicotine; NNIC, nornicotine; NNO, nicotine-1′-N-oxide.

  • * P < 0.05, **P < 0.01 versus AD(s.c.) group.