Nonsynonymous variants identified in cynomolgus and rhesus CYP2D17
| Variant | Exon | Nucleotide Changea | Amino Acid Change | Number of Alleles | Site | ||
|---|---|---|---|---|---|---|---|
| Cynomolgus | Rhesus | ||||||
| Indochina | Indonesia | ||||||
| c.13G>A | 1 | TAGAT(G>A)CACTG | A5T | 0/78 | 1/96 | 0/80 | |
| c.35C>T | TGTGA(C>T)AGTGG | T12I | 0/78 | 1/96 | 24/80 | ||
| c.77G>A | CCGGC(G>A)CCAAC | R26H | 0/78 | 0/96 | 1/80 | ||
| c.83G>A | CCAAC(G>A)TTGGG | R28H | 1/78 | 6/96 | 0/80 | ||
| c.175G>A | GCTTC(G>A)ACCAG | D59N | 2/76 | 0/96 | 0/80 | ||
| c.367T>C | 3 | TGGCG(T>C)GCTAC | R122C | 0/78 | 0/96 | 1/80 | SRS1 |
| c.563C>A | 4 | CGCCT(C>A)CCTCA | S188Y | 0/78 | 38/96 | 0/80 | |
| c.679G>A | 5 | ATGCC(G>A)TCCCC | V227I | 7/72 | 25/96 | 0/76 | |
| c.724C>G | TCCTA(C>G)GCTCC | R242G | 0/72 | 20/96 | 0/76 | SRS3 | |
| c.769G>A | TGACC(G>A)AGCAC | E257K | 0/72 | 2/96 | 0/76 | ||
| c.799C>G | CCCAG(C>G)CACCC | P267A | 0/72 | 0/96 | 12/76 | ||
| c.815C>T | CCTGA(C>T)TGAGG | T272I | 0/72 | 9/96 | 0/76 | ||
| c.819G>C | ACTGA(G>C)GCCTT | E273D | 0/72 | 1/96 | 0/76 | ||
| c.866G>C | 6 | GAGTA(G>C)CTTCA | S289T | 0/78 | 4/96 | 0/80 | |
| c.871A>C | GCTTC(A>C)ATGAA | N291H | 14/78 | 0/96 | 0/80 | ||
| c.877G>A | ATGAA(G>A)AGAAC | E293K | 1/78 | 0/96 | 0/80 | ||
| c.886C>T | ACCTG(C>T)GCATAG | R296C | 2/78 | 1/96 | 1/80 | SRS4 | |
| c.891A>G | CGCAT(A>G)GTGGT | I297M | 0/78 | 25/96 | 3/80 | SRS4 | |
| c.926C>G | GGTGA(C>G)CACCT | T309S | 0/78 | 0/96 | 4/80 | SRS4 | |
| c.952C>T | GGGGC(C>T)TCCTG | L318F | 1/78 | 0/96 | 0/80 | ||
| c.1009A>G | 7 | TTGAC(A>G)ACGTG | N337D | 0/78 | 25/96 | 11/80 | |
| c.1012G>A | ACAAC(G>A)TGATA | V338M | 0/78 | 0/96 | 2/80 | ||
| c.1072G>T | CCACT(G>T)CCGTG | A358S | 0/78 | 0/96 | 1/80 | ||
| c.1150CTA>GTG | TCGAA(CTA>GTG)CAGGG | L384V | 6/78 | 0/96 | 0/80 | ||
| c.1162C>T | GCTTC(C>T)TCATC | L388F | 3/78 | 0/96 | 0/80 | ||
| c.1165A>G | TCCTC(A>G)TCCCT | I389V | 1/78 | 0/96 | 0/80 | ||
| c.1181C>T | 8 | GACGA(C>T)GCTCT | T394M | 0/74 | 0/96 | 1/80 | |
| c.1264G>A | TCCTG(G>A)ATGCT | D422N | 2/74 | 0/96 | 0/80 | ||
| c.1277G>A | GGGCC(G>A)CTTTG | R426H | 6/74 | 52/96 | 60/80 | ||
| c.1322A>G | 9 | CCGCC(A>G)TGCAT | R441H | 72/72 | 96/96 | 77/78 | Heme |
| c.1375T>C | TCACC(T>C)GCCTG | C459R | 1/72 | 0/96 | 0/78 | ||
| c.1411G>A | CCGCC(G>A)GACAG | G471R | 0/72 | 1/96 | 0/78 | ||
| c.1414CA>TG | CCGGA(CA>TG)GCCCC | Q472W | 0/72 | 3/96 | 0/78 | ||
| c.1415A>G | CGGAC(A>G)GCCCC | Q472R | 0/72 | 12/96 | 0/78 | ||
| c.1420C>T | AGCCC(C>T)GGCCC | R474W | 0/72 | 1/96 | 1/78 | ||
| c.1486C>T | CTGTG(C>T)CCCGC | P496S | 0/72 | 2/96 | 0/78 | ||