TABLE 3

CLint values in liver S9 of human, monkey, dog, and rat

No.CompoundsCLint,LS9
HumanMonkeyDogRat
ml/min/mg S9 protein
1Benazepril0.11 ± 0.00780.020 ± 0.0072a0.16 ± 0.017
2Cilazapril0.17 ± 0.00900.15 ± 0.0590.024 ± 0.0140.79 ± 0.057
3Quinapril0.028 ± 0.016aa0.17 ± 0.0068
4Trandolapril0.021 ± 0.0015a0.0031 ± 0.00120.10 ± 0.0023
5Perindopril0.0040 ± 0.000310.0018 ± 0.00031aa
6Ramipril0.061 ± 0.0083a0.0055 ± 0.00150.25 ± 0.0048
7Temocapril0.22 ± 0.0455.0 ± 2.50.074 ± 0.0184.0 ± 1.8
8Oseltamivir0.067 ± 0.00650.011 ± 0.00074aa
9Candesartan cilexetil5.4 ± 0.8016 ± 1.824 ± 9.012 ± 3.9
10Mycophenolate mofetil3.4 ± 0.4110 ± 0.275.2 ± 0.662.0 ± 0.066
11Olmesartan medoxomil0.47 ± 0.0575.4 ± 0.470.72 ± 0.0210.62 ± 0.075
  • a CLint values could not be obtained. The remaining ratio of the compounds incubated for 60 minutes was >90%. (CLint < 0.002 ml/min/mg S9 protein). Each value presents the mean ± S.D. (n = 3).