Formation rate of arachidonic acid metabolites mediated by rat heart, lung, kidney, and liver microsomal fractions
| Compound | Formation Ratea | |||
|---|---|---|---|---|
| Heart | Lung | Kidney | Liver | |
| pmol/mg protein/min | ||||
| 5-HETE | — | 74.9 ± 6.69 | 75.6 ± 5.42 | 60.9 ± 2.67 |
| 8-HETE | 6.28 ± 0.42 | 23.4 ± 1.61 | 27.5 ± 1.81 | 51.4 ± 2.93 |
| 9-HETE | 5.34 ± 0.46 | 20.9 ± 1.22 | 21.4 ± 1.11 | 19.5 ± 1.38 |
| 11-HETE | 6.40 ± 0.41 | 24.8 ± 2.39 | 24.9 ± 1.46 | 103 ± 7.97 |
| 12-HETE | 7.15 ± 0.48 | 34.6 ± 2.21 | 24.3 ± 1.30 | 84.0 ± 6.98 |
| 15-HETE | — | 81.3 ± 5.47 | 90.1 ± 5.33 | 202 ± 12.8 |
| 16-HETE | 2.49 ± 0.23 | 2.47 ± 0.17 | 25.5 ± 1.44 | 234 ± 6.68 |
| 17-HETE | — | — | — | 70.3 ± 1.79 |
| 18-HETE | — | — | — | — |
| 19-HETE | 0.1 ± 0.03 | 0.45 ± 0.02 | 20.0 ± 1.46 | 181 ± 6.96 |
| 20-HETE | 0.49 ± 0.07 | 1.85 ± 0.11 | 258 ± 14.5 | 546 ± 29.4 |
| 5,6-EET | 7.98 ± 0.86 | 19.1 ± 1.18 | 15.4 ± 1.68 | 256 ± 6.79 |
| 8,9-EET | 11.8 ± 0.80 | 10.2 ± 0.57 | 126 ± 6.97 | 505 ± 31.8 |
| 11,12-EET | 26.6 ± 1.04 | 20.5 ± 1.20 | 225 ± 15.6 | 883 ± 47.8 |
| 14,15-EET | 22.6 ± 1.41 | 16.0 ± 1.27 | 86.8 ± 5.55 | 364 ± 35.8 |
↵a Data are the mean and S.E.M. based on at least three individual experiments; —, undetectable formation.