TABLE 2

CLint values obtained in hepatocytes of human, monkey, dog, and rat

Each value presents the mean ± S.D. (n = 3).

No.CompoundsCLint,hepatocytes
HumanMonkeyDogRat
ml/min per 106 cells
1Benazepril0.031 ± 0.00960.0066 ± 0.00260.0094 ± 0.00220.085 ± 0.032
2Cilazapril0.044 ± 0.00170.019 ± 0.00370.0065 ± 0.000770.15 ± 0.0062
3Quinapril0.0061 ± 0.00100.0036 ± 0.00120.0066 ± 0.000520.12 ± 0.012
4Trandolapril0.022 ± 0.00270.0043 ± 0.000250.013 ± 0.00400.041 ± 0.0025
5Perindopril0.0060 ± 0.00120.0025 ± 0.000380.0060 ± 0.00570.0046 ± 0.00080
6Ramipril0.025 ± 0.00140.0038 ± 0.000830.010 ± 0.000550.053 ± 0.017
7Temocapril0.063 ± 0.00660.076 ± 0.0110.028 ± 0.00583.3 ± 1.2
8Oseltamivir0.089 ± 0.0190.0062 ± 0.0032a0.0059 ± 0.0030
9Candesartan cilexetil6.2 ± 1.17.7 ± 0.6414 ± 0.427.0 ± 0.54
10Mycophenolate mofetil0.16 ± 0.110.16 ± 0.112.3 ± 0.260.30 ± 0.043
11Olmesartan medoxomil0.12 ± 0.0370.24 ± 0.100.072 ± 0.0230.81 ± 0.10
  • a CLint values could not be obtained. The remaining ratio of the compounds incubated for 120 minutes was >90%. Each value presents the mean 6 S.D. (n = 3).