Plasma trans-3′-hydroxycotinine (3HC) and norcotinine (NCOT) levels in EA and AD rats following s.c. nicotine
Data are presented as mean (S.D.).
| Time Point | Plasma 3HC Level | Plasma NCOT Level | ||
|---|---|---|---|---|
| EA | AD | EA | AD | |
| ng/ml plasma | ||||
| 10 min | < LOQ | < LOQ | < LOQ | < LOQ |
| 30 min | < LOQ | 1.4 (3.7) | 2.4 (0.8) | 2.7 (3.8) |
| 1 h | 1.4 (0.8) | 1.4 (0.1) | 3.5 (1.3) | 3.3 (0.3) |
| 2 h | 2.9 (1.6) | 2.8 (0.9) | 7.7 (3.1) | 5.2 (1.8) |
| 4 h | 2.9 (1.2) | 4.0 (1.9) | 7.6 (2.6) | 7.8 (3.1) |
| 8 h | 1.7 (0.4) | 4.0 (0.5) | 3.8 (0.7) | 6.3 (1.0) |