Pharmacokinetic parameters (mean ± S.D., n = 3 each phenotype) in the slow and fast metabolizer phenotypes of male SD rats after the intravenous and oral administrations of Cpd-D
| Slow Metabolizer | Fast Metabolizer | ||||||
|---|---|---|---|---|---|---|---|
| i.v. | PO | i.v. | PO | ||||
| 1 mg/kg | 1 mg/kg | 3 mg/kg | 1 mg/kg | 1 mg/kg | 3 mg/kg | ||
| AUC0–∞ | (μM·h) | 8.04 ± 0.34 | 5.86 ± 0.97 | 18.8 ± 4.0 | 2.17 ± 0.30*** | 0.48 ± 0.07*** | 2.03 ± 0.73** |
| t1/2 | (h) | 1.66 ± 0.27 | — | — | 0.26 ± 0.02*** | — | — |
| Cmax | (μM) | — | 2.91 ± 0.55 | 5.96 ± 2.42 | — | 0.50 ± 0.08** | 1.29 ± 0.50* |
| CLp | (ml/min/kg) | 4.86 ± 0.20 | — | — | 18.2 ± 2.7** | — | — |
| Vdss | (l/kg) | 0.28 ± 0.03 | — | — | 0.29 ± 0.01 | — | — |
—, not applicable.
Significantly different from slow metabolizers (*P < 0.05, **P < 0.01, and ***P < 0.001).