TABLE 5

CLint values in kidney S9 of human, monkey, dog, and rat

No.CompoundsCLint,KS9
HumanMonkeyDogRat
ml/min/mg S9 protein
9Candesartan cilexetil0.61 ± 0.0942.3 ± 0.0277.1 ± 0.421.8 ± 1.2
10Mycophenolate mofetil0.12 ± 0.0125.3 ± 0.515.6 ± 0.851.0 ± 0.14
11Olmesartan medoxomil0.21 ± 0.0480.86 ± 0.0670.13 ± 0.0480.38 ± 0.030
  • Each value presents the mean ± S.D. (n = 3).