Model-derived parameters for passive permeability, fraction unbound, and active uptake determined in human embryonic kidney 293 cells
Reported values represent the model derived estimate (95% confidence interval).
| PF-049 | PF-051 | Units | |
|---|---|---|---|
| P | 5.23 (4.06 .. 6.78) | 4.43 (3.4 .. 5.8) | (×10−6 cm/s) |
| Pn | 1868 (1637 .. 2132) | 18.2 (13.9 .. 23.8) | (×10−6 cm/s) |
| fucell | 0.2 (0.15 .. 0.237) | 0.67 (0.63 .. 0.7) | No units |
| Cluptake 1b1 (6.0) | 2.0 (1.7 .. 2.4) | 0.77 (0.72 .. 0.81) | (×10−6 ml/s) |
| Cluptake 1b1 (7.4) | 2.6 (2.3 .. 3.0) | 0.38 (0.34 .. 0.41) | (×10−6 ml/s) |
| Cluptake 1b3 (6.0) | 0.59 (0.4 .. 0.88) | 0.38 (0.34 .. 0.43) | (×10−6 ml/s) |
| Cluptake 1b3 (7.4) | 1.1 (0.85 .. 1.35) | 0.25 (0.22 .. 0.28) | (×10−6 ml/s) |