TABLE 3

AUC^{^a} estimated by nonparametric analysis and PBPK model

	Study Type	AUC_plasma_{, 0–2.5 hrs}	AUC_plasma_{, 0–12 hrs}
		h∙μg/l	h∙μg/l
Nonparametric analysis^{^a}	Intravenous (Stangier et al., 2000b)	449	558
Nonparametric analysis^{^a}	Intravenous (Stangier et al., 2000a)	664	852
PBPK model^{^b}	Rodgers and Rowland (2006) Kp^{^c}	731	—
PBPK model^{^b}	PET Kp^{^c}	709	—
	Without enterohepatic recirculation ^{^d}	—	742
	With enterohepatic recirculation^{^d}	—	946

↵^a All studies were performed with 40-mg telmisartan intravenous infusion dosing.
↵^b AUC were estimated using trapezoid integration.
↵^c Calculated without enterohepatic recirculation.
↵^d Calculated with PET Kp.