Estimated FG or FAFG for substrate drugs of CYP2C9, CYP2C19, and CYP2D6 with DDI, DDI i.v., and i.v./p.o. methods
Estimated FG is shown for the DDI, DDI i.v., and GFJ methods, whereas estimated FAFG is shown for the i.v./p.o. method. The n values refer to the number of studies used for evaluation of FG (see Supplemental Table 2). FG or FAFG was reported as 1 when a larger value than 1 was calculated. Data are presented as the mean.
| Drug | Metabolic Enzyme | Estimated FG or FAFG | |||||
|---|---|---|---|---|---|---|---|
| DDI | DDI i.v. | i.v./p.o. | |||||
| n | n | n | |||||
| Tolbutamide | CYP2C9 | 0.92 | 1 | 0.92 | 1 | 1.00 | 1 |
| Diazepam | CYP2C19 | 1.00 | 1 | 1.00 | 1 | 1.00 | 1 |
| Brofaromine | CYP2D6 | 1.00 | 1 | — | — | ||
| Debrisoquine | CYP2D6 | 0.87 | 1 | — | — | ||
| Dexfenfluramine | CYP2D6 | 0.84 | 1 | 1.00 | 1 | 1.00 | 1 |
| Codeine | CYP2D6 | 0.75 | 1 | 0.71 | 1 | 1.00 | 1 |
| Tropisetron | CYP2D6 | 0.75 | 1 | ||||
| Metoprolol | CYP2D6 | 0.73 | 2 | 1.00 | 2 | 1.00 | 2 |