TABLE 2

Observed distributions of P-glycoprotein substrate verapamil to brain in control, pentylenetetrazole, phenytoin, and spontaneous model of epilepsy mice

Mice received constant intravenous infusion of verapamil to the jugular vein at a rate of 500 nmol/h per kg following 1-minute rapid infusion (500 nmol/min per kg). The plasma and brain concentrations were measured at 45 minutes, and the brain-to-plasma concentration ratio (K_{p brain}) values were calculated by dividing the brain concentration by the plasma concentration. Each value represents the mean ± S.E.M. (n = 3–4).