Individual pharmacokinetic parameters of TB in pregnant and postpartum baboons following a 1-mg/kg i.v. bolus dose of BUP
| Midpregnancy | Late Pregnancy | Postpartum | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cmax | tmax | AUC0–∞ | Cmax | tmax | AUC0–∞ | Cmax | tmax | AUC0–∞ | |
| ng/ml | h | h·ng/ml | ng/ml | h | h·ng/ml | ng/ml | h | h·ng/ml | |
| Study animal | |||||||||
| 2 | 1.52 | 2.00 | 9.83 | 1.65 | 1.00 | 6.57 | |||
| 3 | 1.74 | 0.75 | 5.90 | 1.35 | 1.00 | 5.48 | 1.75 | 1.00 | 6.47 |
| 5 | 2.22 | 0.75 | 7.67 | 3.24 | 0.75 | 11.51 | 1.84 | 0.50 | 6.02 |
| Mean | 1.98 | 0.75 | 6.8 | 2.04 | 1.25 | 8.9 | 1.75 | 0.83 | 6.4 |
| S.D. | 0.34 | 0.00 | 1.3 | 1.05 | 0.66 | 3.1 | 0.10 | 0.29 | 0.3 |