Individual pharmacokinetic parameters of OH-BUP in pregnant and postpartum baboons following a 1-mg/kg i.v. bolus dose of BUP
P values from repeated-measures ANOVA: Cmax, 0.373; tmax, 0.751; AUC0–∞, 0.102.
| Midpregnancy | Late Pregnancy | Postpartum | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cmax | tmax | AUC0–∞ | Cmax | tmax | AUC0–∞ | Cmax | tmax | AUC0–∞ | |
| ng/ml | h | h·ng/ml | ng/ml | h | h·ng/ml | ng/ml | h | h·ng/ml | |
| Study animal | |||||||||
| 1 | 85.5 | 0.5 | 211.0 | 110.7 | 0.5 | 310.1 | |||
| 2 | 99.1 | 0.75 | 344.7 | 232.1 | 0.5 | 636.9 | |||
| 3 | 62.5 | 0.5 | 109.6 | 26.3 | 0.75 | 71.3 | 72.3 | 0.25 | 201.0 |
| 4 | 108.0 | 0.5 | 288.3 | 98.7 | 0.5 | 292.5 | 83.5 | 1 | 302.7 |
| 5 | 82.8 | 0.75 | 165.3 | 66.1 | 1 | 200.2 | 177.9 | 0.5 | 315.9 |
| Mean | 84.7 | 0.6 | 194 | 72.6 | 0.8 | 227 | 135 | 0.6 | 353 |
| S.D. | 18.6 | 0.1 | 76 | 34.5 | 0.2 | 120 | 68 | 0.3 | 165 |