TABLE 1

Demographic information of the healthy volunteers

Data are presented as the mean ± S.D.

Group	No CYP3A5*1 (n = 8)	One CYP3A5*1 (n = 8)	Two CYP3A5*1 (n = 8)
Age (yr)	45.1 ± 12.7	39.4 ± 11.7	38.0 ± 8.8
Weight (kg)	84.0 ± 15.6	76.7 ± 14.9	73.8 ± 14.5
Body mass index (kg/m²)^{^a}	26.4 ± 4.5	24.9 ± 3.6	23.8 ± 3.6
Creatine clearance (ml/min)^{^b}	114.3 ± 28.8	103.2 ± 15.2	100.1 ± 30.2
Total protein (g/dl)	7.0 ± 0.4	7.5 ± 0.4	7.1 ± 0.3
Albumin (g/dl)	4.6 ± 0.3	4.6 ± 0.1	4.5 ± 0.3
Bilirubin (mg/dl)	0.5 ± 0.2	0.4 ± 0.3	0.5 ± 0.2
Alkaline phosphatase (IU/L)	73.3 ± 16.7	74.9 ± 17.0	54.9 ± 14.3
Alanine transaminase (IU/L)^{^b}	17.5 ± 4.5	18.5 ± 6.8	13.9 ± 3.4
Aspartate transaminase (IU/L)	19.6 ± 2.9	22.4 ± 4.9	20.0 ± 2.9
Female/male volunteers (n)	2/6	1/7	3/5

↵^a Calculated as weight/(height × height).
↵^b Calculated as [(140 − age [yr]) × weight (kg)]/[72 × serum creatinine concentration (mg/dl)] (multiply by 0.85 for female sex).