TABLE 1

Drug data set

The numbers in this table indicate the numbers of drugs in our data set that are primarily eliminated through each clearance pathway as stratified by charge. The numbers of drugs in each clearance pathway vary greatly, and drugs in some categories display a strong relationship with their charge.

ChargeClearance Pathway
CYP3A4CYP2C9CYP2D6RenalOATPTotal
Anion0110181847
Cation or neutral5211823094
Total5212184118141