Regression analysis of the association between CYP2C19 genotype and plasma bupropion or its metabolites AUC (study 1)
| BUP AUC24 (r2 = 0.146) | OH-BUP AUC24 (r2 = 0.007) | EB AUC24 (r2 = 0.277) | TB AUC24 (r2 = 0.274) | |||||
|---|---|---|---|---|---|---|---|---|
| B (95% CI) | P | B (95% CI) | P | B (95% CI) | P | B (95% CI) | P | |
| CYP2C19 *2 | 132 (25,239) | 0.017* | 613 (-1966,3191) | 0.634 | 266 (113.3,418.3) | 0.001* | 1838 (744,2933) | 0.002* |
| CYP2C19 *17 | −23 (−118.6,73.5) | 0.638 | −236 (−2557,2085) | 0.838 | −91 (−228,47) | 0.189 | −756 (−1741,229) | 0.129 |
AUC24, AUC for 24 hours; CI, confidence interval.
↵* Indicates statistical significance.