TABLE 1
Mass spectral characteristics of the metabolites of PF-04937319
| Metabolitea | MH+ | Structure | Fragment Ions |
|---|---|---|---|
| PF-04937319 | 433.1619 |  | 342.1084, 324.0979, 296.1029, 281.0555, 253.0607, 225.0657 |
| M1 | 419.1462 |  | 310.0822, 282.0873 |
| M2 | 449.1567 |  | 431.1465, 419.1467, 388.1041, 360.1091, 281.0558 |
| M3 | 342.1084 |  | 324.0980, 296.1029, 281.0557, 253.0607, 225.0659 |
| M3a | 435.1411 |  | 417.1302, 405.1306 |
| M4 | 328.0929 |  | 310.0822 |
| M5 | 449.1568 |  | 431.1462, 324.0979 |
| M6 | 384.1302 |  | 367.1040, 341.1246 |
| M7 | 358.1040 |  | 340.0932, 328.0932, 297.0506, 269.0559 |
| M8 | 449.1568 |  | 431.1463, 358.1035, 340.0928, 312.0977, 297.0504, 168.0766 |
| M9 | 341.1244 |  | 324.0982 |
| M10 | 435.1411 |  | 417.1306, 326.0773, 298.0820, 154.0608, 136.0502 |
| M11 | 465.1518 |  | 447.1408, 435.1410, 404.0989, 376.1041, 338.0771, 297.0507 |
| M12 | 421.1624 |  | 403.1574, 324.0979, 298.1189 |
| M13 | 451.1359 |  | 433.1255, 421.1254, 404.0987, 324.0616 |
| M14 | 518.1405 |  | 342.1084 |
| M15 | 358.1033 |  | 340.1033, 315.0614, 297.0505 |
| M16 | 344.0873 |  | 326.0773, 297.0519 |
↵a Metabolite numbering system is based on individual metabolite tR on reversed-phase HPLC (see Fig. 2).