TABLE 2
Kinetic constants for inactivation of CYP3A4 by SCH 66712 and EMTPP
Inactivator
K
I
k
inact
k
inact
/
K
I
µM
min
−1
min
−1
µM
−1
SCH 66712
1.6 ± 0.7
0.211 ± 0.024
0.013
EMTPP
11.8 ± 2.6
0.044 ± 0.004
0.0037