TABLE 1

Demographics of skin donors participating in the study and activities of carbazeran 4-hydroxylation and zoniporide 2-hydroxylation measured in the corresponding human skin explants

Metabolites formed in incubations, 4-hydroxycarbazeran and 2-oxo-zoniporide, were detected and quantified in both skin punch and corresponding medium.

Skin Donor	Gender	Race	Age	Skin Anatomic Region	Smoking	Alcohol Use	Carbazeran 4-Hydroxylation		Zoniporide 2-Hydroxylation
Skin Donor	Gender	Race	Age	Skin Anatomic Region	Smoking	Alcohol Use	Mean	S.D.	Mean	S.D.
			yr				pmol⋅mg skin^–1⋅h^–1
1	Female	Caucasian	72	Abdomen	Never	Occasionally	0.337	0.040	0.082	0.004
2	Female	Not specified	57	Breast	Never	Never	1.985	0.043	0.213	0.005
3	Male	Caucasian	45	Abdomen	Daily	Occasionally	1.429	0.031	0.165	0.004
4	Female	Caucasian	46	Abdomen	Never	Never	1.058	0.018	0.125	0.010
5	Female	Caucasian	63	Inguinal	Never	Occasionally	1.364	0.299	0.152	0.006
6	Female	Not specified	58	Abdomen	Never	Never	1.481	0.020	0.157	0.029
7	Female	Caucasian	47	Breast	Never	Occasionally	1.430	0.023	0.176	0.016
8	Female	Caucasian	72	Breast	Never	Occasionally	1.244	0.064	0.153	0.010
9	Female	Caucasian	41	Abdomen	Daily	Occasionally	1.952	0.181	0.217	0.009
10	Female	Black	45	Axillary	Occasionally	Occasionally	1.248	0.144	0.210	0.016
11	Female	Caucasian	52	Inguinal	Daily	Occasionally	1.256	0.023	–	–
12	Male	Caucasian	55	Abdomen	Never	Occasionally	0.789	0.069	–	–
13	Female	Caucasian	55	Inguinal	Former	1–2 days/wk	–^{^a}	–^{^a}	–^{^a}	–^{^a}
							Summary Statistics
					No. of donors tested		12		10
					Average (± S.D.) activity rate (pmol⋅mg skin^–1⋅h^–1)		1.301 ± 0.449		0.164 ± 0.043
					Coefficient of variation		34%		26%
					Activity range (min–max) (pmol⋅mg skin^–1⋅h^–1)		0.337–1.985		0.082–0.217

–, not tested.
↵^a Enzyme kinetics assays only.