Effects of saline, LPS, MOPC 31C (control) antibody, and ANC28.1 antibody on the release of cytokines in whole human blood
Values represent cytokine concentration (in picograms per milliliter).
| Cytokine | Treatment | |||
|---|---|---|---|---|
| Salinea | LPSa | MOPC 31C Antibodyb | ANC28.1 Antibodyb | |
| Interferon–γ | 4.68 ± 2.67 | 5160 ± 4640 | 2.11 (1.64, 2.58) | 109 (107, 112)* |
| Interleukin-1β | 2.27 ± 1.59 | 5520 ± 1700 | 0.527c | 18.1 (17.2, 19.0) |
| Interleukin-2 | 8.15 ± 3.74 | 107 ± 15.7 | 8.04 (3.19, 12.9) | 749 (705, 793)* |
| Interleukin-6 | 4.69 ± 2.76 | 12000 ± 876 | 1.18 (0.610, 1.76) | 110 (104, 116)* |
| Interleukin-8 | 796 ± 691 | 10000 ± 3640 | 492 (513, 471) | 5400 (5150, 5650)* |
| Interleukin-10 | 4.19 ± 1.27 | 747 ± 219 | 1.70 (1.20, 2.19)** | 16.3 (15.7, 17.0)* |
| Interleukin-12p70 | 7.18 ± 4.83 | 54.5 ± 8.58 | 2.60c | BLQ |
| Tumor necrosis factor-α | 8.50 ± 4.32 | 5830 ± 2700 | 5.73 (4.71, 6.76) | 227 (215, 238)* |
| Granulocyte monocyte-CSF | 15.1 ± 9.74 | 204 ± 84.9 | 21.0 (24.7, 17.3) | 540 (844, 235) |
BLQ, below level of quantitation; CSF, colony-stimulating factor.
↵a Values are the mean ± standard deviation of three determinations in blood from four donors.
↵b Values are the average of two determinations (shown in parentheses) in blood from a single donor.
↵c Value from a single determination (the second determination was below level of quantitation).
↵* Statistically different from MOPC 31C control (t test: paired two samples for means, one-tail, P < 0.05); **Statistically different from saline control (t test: two-sample assuming equal variances, one-tail, P < 0.05).