Recovery and matrix effect of two levels of quality control (QC, n = 6) standards for MA, 4-OH MA, AM, 4-OH AM, and norephedrine in monkey plasma
All CC and QC standard values were presented in one decimal place except CC-8 and 9, and LQC and LLOQ which were presented in two decimal places.
| Name | Nominal concentration. (ng/ml) | Recovery | Matrix Effect | ||
|---|---|---|---|---|---|
| HQC | LQC | HQC | LQC | ||
| 640.0 | 14.94 | 640.0 | 14.94 | ||
| MA | Actual (ng/ml) | 685.8 | 13.15 | 625.1 | 14.5 |
| % Accuracy | 107.2 | 88.0 | 97.7 | 97.1 | |
| % CV | 6.7 | 13.3 | 9.5 | 15.8 | |
| 4-OH MA | Actual (ng/ml) | 619.7 | 12.8 | 598.9 | 14.4 |
| % Accuracy | 96.8 | 85.7 | 93.6 | 96.4 | |
| % CV | 10.4 | 15.1 | 16.4 | 13.6 | |
| AM | Actual (ng/ml) | 639.2 | 14.3 | 599.6 | 14.9 |
| % Accuracy | 99.9 | 95.7 | 93.7 | 99.7 | |
| % CV | 6.2 | 8.3 | 10.6 | 7.8 | |
| 4-OH AM | Actual (ng/ml) | 699.2 | 16.3 | 659.6 | 16.5 |
| % Accuracy | 109.3 | 109.1 | 103.1 | 110.4 | |
| % CV | 9 | 10.8 | 3.6 | 7.5 | |
| Norephedrine | Actual (ng/ml) | 640 | 14.94 | 640 | 14.94 |
| % Accuracy | 113.9 | 117.8 | 114.7 | 119.8 | |
| % CV | 7.6 | 9.7 | 11.8 | 8.2 | |
CV (precision), coefficient of variation, HQC, high QC; LQC, lower QC; MQC, middle QC.