The main pharmacokinetic parameters of rosuvastatin (5 mg/kg) after oral administration with or without TB-2 (30, 60, 180 mg/kg)
Each value is the mean ± S.D. (n = 4).
| Parameter | Rosuvastatin | Rosuvastatin + TB-2 (30 mg/kg) | Rosuvastatin + TB-2 (60 mg/kg) | Rosuvastatin + TB-2 (180 mg/kg) |
|---|---|---|---|---|
| AUC0-10h (h⋅ng/ml) | 113.0 ± 7.8 | 154.3 ± 12.3 | 227.2 ± 52.8 | 282.2 ± 74.4 |
| Cmax (ng/ml) | 46.1 ± 13.9 | 99.2 ± 16.5 | 102.7 ± 26.4 | 97.0 ± 22.8 |