Summary of literature-derived UGT abundances in the liver, intestine, and kidney
| UDP-glucuronosyltransferase | Mean Liver Abundance from Human Liver Microsome Samples | Mean Intestinal Abundance | Mean Kidney Abundance |
|---|---|---|---|
| pmol/mg | |||
| 1A1 | 20–35a, 18.3b, 21.5c, 22.4d, 33.5e, 120f, 0.133g, 36.2h | 6–7a | 7b, BLQg |
| 1A3 | 9.9b, 17.3e, 7.9h | BLQb | BLQb |
| 1A4 | 4.6b, 5.4h | 5.3b | 11b |
| 1A5 | ≥0.23h | NA | NA |
| 1A6 | 3–5a, 4.6b,114e, 0.452g, 9.7h | 2.3b | 2b,BLQg |
| 1A7 (extrahepatic) | BLQb, ≥0.23h | 8.4b | 14b |
| 1A8 (extrahepatic) | BLQb, ≥ 0.23h | 6.1b | 8b |
| 1A9 | 26.7b, 25.9e, 23.1h | 6.6b | 81b |
| 1A10 (extrahepatic) | BLQb, ≥0.23h | 4.7b | 18b |
| 2B7 | 9.7c, 96d, 84.3e, 80.1h | NA | NA |
| 2B10 | 6.5h | NA | NA |
| 2B15 | 61.8e, 32.8h | NA | NA |
| 2B17 | 8.1h | NA | NA |
BLQ, below the limit of quantification; NA, not available.
↵a Fallon et al., 2008 (n = 10).
↵b Harbourt et al., 2012 (n = 9).
↵c Sato et al., 2012 (n = 16).
↵d Schaefer et al., 2012 (n = 3).
↵e Schaefer et al., 2012 (n = 17).
↵f Sridar et al., 2013 (n = 15).
↵g Milne et al., 2011 (n = 29).
↵h Fallon et al., 2013 (n = 60).