Major metabolic clearance mechanisms involved in the elimination of drugs
| Clearance Mechanism | Possible Enzymes/Proteins Involved |
|---|---|
| Oxidative metabolism | P450, AO, FMO, MAO, Mo-CO, peroxidases |
| Conjugative metabolism | UGT, ST, GST, NAT, methyl transferase |
| Hydrolytic metabolism | Esterases, amidases, epoxide hydrolase, P450 |
| Reductive metabolism | P450, ketoreductase, Mo-CO |
FMO, flavin monooxygenase; GST, glutathione S-transferase; MAO, monoamine oxidase; Mo-CO, molybdenum cofactor; NAT, N-acteyl transferase; ST, sulfotransferase.