TABLE 1

Pharmacokinetic parameters for plasma nicotine and cotinine in TG/Cyp2abfgs-null and Cyp2abfgs-null mice

Data from Fig. 5 were used for calculation of pharmacokinetic parameters. Values shown represent means ± S.D. (n = 3–4).

Analyte	Animals	t_1/2	T_max	C_max	AUC_0–240min	CL/F
		min		ng/ml	ng·h/ml	ml/min
Nicotine	Cyp2abfgs-null, vehicle-treated	94 ± 50	5 ± 0	426 ± 181	364 ± 195	1.4 ± 0.6
	TG/Cyp2abfgs-null, vehicle-treated	77 ± 53	5 ± 0	173 ± 52	171 ± 18	2.5 ± 0.4*
Cotinine	Cyp2abfgs-null, vehicle-treated	N/A	120 ± 0	102 ± 16	300 ± 39	N/A
	TG/Cyp2abfgs-null, vehicle-treated	N/A	120 ± 0	186 ± 32*	577 ± 96**	N/A
Nicotine	Cyp2abfgs-null, PB-treated	103 ± 62	5 ± 0	350 ± 51	205 ± 32	1.6 ± 0.1
	TG/Cyp2abfgs-null, PB-treated	84 ± 19	5 ± 0	199 ± 76*	123 ± 9**	3.1 ± 0.3**
Cotinine	Cyp2abfgs-null, PB-treated	N/A	120 ± 0	87 ± 23	263 ± 79	N/A
	TG/Cyp2abfgs-null, PB-treated	N/A	60 ± 0**	317 ± 17**	971 ± 27**	N/A

N/A, not applicable; *P < 0.05, **P < 0.01, compared with corresponding Cyp2abfgs-null value