TABLE 1

Expression of phase II metabolic enzymes in human skin

Literature reports are based on either mRNA expression or detection of the corresponding enzymes at the protein level.

FamilyIndividual Enzymes DetectedReference
UGT1A6, 1A8, 1A10a, 2A1, 2A3, 2B4, 2B15, 2B17, 2B28Luu-The et al., 2009; Hu et al., 2010
SULT1A1a, 1A2, 1A3, 1A4, 1B1, 1E1a, 1E2, 2A1, 2B1aDooley et al., 2000; Higashi et al., 2004; Luu-The et al., 2009; Hu et al., 2010; Kushida et al., 2011
NATNAT1a, NAT2Luu-The et al., 2009; Bonifas et al., 2010a; Hu et al., 2010; van Eijl et al., 2012
COMTSingle human gene is detectedLuu-The et al., 2009; Hu et al., 2010; van Eijl et al., 2012
GSTαa, μa, Πa, Θ, ζ, ΩBlacker et al., 1991; Raza et al., 1991; Luu-The et al., 2009; Hu et al., 2010; van Eijl et al., 2012

  • ↵a Enzymes with higher reported expression.