TABLE 3

Michaelis-Menten kinetic parameters for warfarin reduction in control and CKD rat liver cytosol and microsomes

Data are presented as mean ± S.E.M. of 10 rats in each group.

Alcohol 1 (RS/SR)Alcohol 2 (RR/SS)
KmVmaxKmVmax
μMpmol/mg protein 
per minuteμMpmol/mg protein 
per minute
Cytosol
Control352.0 ± 59.6538.0 ± 1.971091 ± 167.48.43 ± 0.609
CKD359.3 ± 64.0623.3 ± 1.29***1149 ± 127.18.74 ± 0.466
Microsomes
Control446.9 ± 174.79.57 ± 1.25158.0 ± 105.637.7 ± 6.17
CKD365.6 ± 95.825.49 ± 0.45**Not fit to modelNot fit to model
  • ** P < 0.01 compared with control, ***P < 0.001 compared with control.