TABLE 5

Physicochemical properties of compounds used in this study

Compound	Log P^{^a}	Log D^{^a} (pH 7.4)	pK_a/pK_b^{^a}	Polar Surface Area^{^b}	Solvent-Accessible Surface Area^{^b}	Molecular Weight
				Å²
4-Methylumbelliferone	2.43	2.34	pK_a 8.00	46.53	230.19	176.17
17β-Estradiol	4.15	4.15	pK_a 10.27	40.46	436.59	272.38
Indomethacin	4.25	0.98	pK_a 3.96	68.53	476.23	357.79
Diclofenac	4.55	1.44	pK_a 4.18	49.33	361.15	296.15
Triclosan	5.34	5.20	pK_a 7.80	29.46	318.47	289.54
Minoxidil	−0.41	−0.42	pK_b 5.54	93.63	291.22	209.25
p-Toluidine	1.53	1.53	pK_b 5.04	26.02	182.92	107.15
Procainamide	1.32	−0.56	pK_b 9.09	58.36	406.46	235.33
4-Nitrocatechol	1.68	1.03	pK_a 6.87	86.28	198.73	155.11
2,3-Dihydroxynaphthalene	2.11	2.10	pK_a 9.10	40.46	220.46	160.17
1-Chloro-2,4-dinitrobenzene	2.06	2.06	n.a.	91.64	233.30	202.55

n.a., not applicable.
↵^a Log P, Log D (pH 7.4), and pK_a or pK_b were calculated with ACD Laboratories software.
↵^b Polar surface area and solvent-accessible surface area were calculated by ChemAxon software.