TABLE 1

Potential effects of cytokines on the activities of cytochrome P450 DMEs

Compiled from data in Abdel-Razzak et al. (1993), Renton (2004, 2005), Sunman et al. (2004), Aitken et al. (2006), Aitken and Morgan (2007), Huang et al. (2010), Christensen and Hermann (2012), and Dickmann et al. (2012). The arrows indicate the following: ↓, enzyme activity down-regulated; ↑, enzyme activity up-regulated; ↔, no effect on enzyme activity. Multiple arrows indicate divergent data.

Cytokine	Cytochrome P450 Enzyme
Cytokine	CYP1A2	CYP2B6	CYP2C8	CYP2C18	CYP2C9	CYP2C19	CYP2D6	CYP3A4	CYP2E1
IL-1	↓	↓ ↔	↓	↔	↔	↔		↓	↓
IL-2	↓	↓			↓	↓		↓	↓
IL-4	↓	↑						↑ ↔	↑
IL-6	↓	↓	↓	↔	↓	↓		↓	↓
IL-10		↔			↓			↓ ↑
TNF-α	↓	↑ ↓ ↔	↓	↔	↔	↓ ↔		↓	↓
IFN-α	↓
IFN-α-2b	↓					↓	↓		↓
IFN-γ	↓	↓	↓	↔	↔	↔		↓
TGF	↓	↑ ↓ ↔	↓	↔	↓	↓		↓